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PRP for Shoulder Arthritis: A Clinical Overview

PRP for Shoulder Arthritis: A Clinical Overview

Jun 20, 2025

Oscar Tellez

PRP for Shoulder Arthritis: A Clinical Overview

Shoulder arthritis can reduce mobility and cause chronic discomfort, limiting daily function. Platelet-Rich Plasma (PRP) is one option being explored to support joint care in such cases. PRP uses concentrated platelets from the patient's own blood to deliver biologically active proteins into the affected area. This article outlines how PRP works, its relevance in managing shoulder arthritis, and clinical considerations for healthcare providers.

Understanding Shoulder Arthritis

What Happens in Shoulder Arthritis? 

Shoulder arthritis involves inflammation and cartilage breakdown in the glenohumeral joint. It may lead to stiffness, reduced range of motion, and persistent pain. Causes may include wear and tear (osteoarthritis), autoimmune activity (rheumatoid arthritis), or trauma.

Traditional Treatment Options 

Conventional care often includes physical therapy, anti-inflammatory medications, corticosteroid injections, and surgical interventions such as joint replacement in severe cases. These approaches aim to manage symptoms but do not reverse tissue degeneration.

What Is PRP and How Does It Work?

Defining PRP 

PRP is a concentration of platelets in a small volume of plasma. It is prepared by centrifuging a patient’s blood to isolate platelets, which contain growth factors and signaling molecules.

How PRP Works

  • Platelets release growth factors including PDGF, TGF-β, and VEGF

  • These factors may support cell signaling and tissue response

  • PRP is injected into the joint under sterile technique, sometimes with ultrasound guidance

The goal is to create a favorable environment for soft tissue support and modulation of inflammation. It does not regrow cartilage but may influence joint environment.

PRP for Shoulder Arthritis: Clinical Considerations

Patient Selection 

Patients with mild to moderate shoulder arthritis who want to avoid surgery may be candidates. Exclusion criteria often include joint instability, active infection, or advanced joint collapse.

Procedure Overview

  1. Blood is drawn from the patient

  2. It is centrifuged using a PRP preparation system

  3. The platelet-rich layer is extracted and injected into the shoulder

The process typically takes under one hour and is performed in outpatient settings.

Expected Outcomes 

PRP may help reduce symptoms such as stiffness and discomfort. Duration of effect can vary. Some patients may need repeat treatments.

Limitations and Considerations

  • Not a substitute for surgery in advanced cases

  • Variable response depending on individual biology and joint condition

  • Should be used with informed consent and realistic expectations

Safety and Regulatory Context

Safety Profile 

As an autologous product, PRP carries a low risk of adverse reaction. Sterile handling and proper technique reduce infection risk.

Regulatory Guidance 

Providers must use FDA-cleared devices for blood handling and adhere to clinical standards. Claims regarding outcomes must align with published evidence and avoid overstatements.

Practical Integration into Practice

Equipment and Setup 

Clinics offering PRP need:

  • A centrifuge system for PRP preparation

  • Training in phlebotomy and injection technique

  • Patient screening protocols

Patient Communication 

Educational materials and transparent discussions are essential. Patients should understand that PRP is not a guaranteed fix but may offer supportive value.

How Accretion Portal Supports Providers 

Accretion Portal supplies PRP systems and provides support for clinicians integrating regenerative tools. We help providers:

  • Select suitable PRP preparation systems

  • Understand handling and preparation techniques

  • Schedule educational sessions and walkthroughs

Our approach focuses on responsible implementation, patient safety, and efficient use of biologic tools.

Learn More or Get Guidance 

Interested in learning more about how PRP may support joint care in your practice? Book a strategy call with the Accretion Portal team. We’ll help assess your goals and outline your next steps.

Schedule a Free Strategy Call
Phone: 800-307-1194